| Autor: |
C E, Severn, A M, Eissa, C R, Langford, A, Parker, M, Walker, J G G, Dobbe, G J, Streekstra, N R, Cameron, A M, Toye |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Biomaterials. 225 |
| ISSN: |
1878-5905 |
| Popis: |
Haematopoiesis, the process of blood production, occurs from a tiny contingent of haematopoietic stem cells (HSC) in highly specialised three-dimensional niches located within the bone marrow. When haematopoiesis is replicated using in vitro two-dimensional culture, HSCs rapidly differentiate, limiting self-renewal. Emulsion-templated highly porous polyHIPE foam scaffolds were chosen to mimic the honeycomb architecture of human bone. The unmodified polyHIPE material supports haematopoietic stem and progenitor cell (HSPC) culture, with successful culture of erythroid progenitors and neutrophils within the scaffolds. Using erythroid culture methodology, the CD34 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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