Production of [17F]CH3F (t1/2=65 s), an improved PET tracer for rCBF measurement

Autor: T E, Barnhart, A K, Converse, K A, Dabbs, M J, Schueller, C K, Stone, R J, Nickles, A D, Roberts
Rok vydání: 2004
Předmět:
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 62(4)
ISSN: 0969-8043
Popis: Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.
Databáze: OpenAIRE