| Autor: |
Jun, Kurai, Tadashi, Igishi, Hisashi, Suyama, Masahiro, Kodani, Yasushi, Fukuoka, Masanori, Miyata, Hirokazu, Touge, Yasuaki, Hasegawa, Kazuto, Yasuda, Yutaka, Hitsuda, Eiji, Shimizu |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 33(3) |
| ISSN: |
0385-0684 |
| Popis: |
The patient was a 62-year-old man with small-cell lung cancer (limited disease). He was treated with cisplatin (CDDP) plus etoposide(ETP) and concurrent radiotherapy as first-line treatment. Although a complete response was achieved, his pro-GRP elevated 10 months later. He was treated with several anticancer agents including, CDDP plus irinotecan (CPT-11), CPT-11, paclitaxel and amrubicin (AMR). Although, as a monotherapy, the administration of AMR (30 mg/m(2)) for 3 consecutive days (3-day schedule) seemed to be most effective, severe myelosuppression was observed, and this treatment was discontinued. We changed the treatment schedule to biweekly administration of AMR (30 mg/m(2)). The level of pro-GRP decreased, and it was maintained at a similar level for 7 months. No severe toxicity was observed during this period. This case suggests that the bi-weekly administration of AMR may be a useful option for the treatment of small-cell lung cancer when a 3-day AMR schedule is highly myelosuppressive. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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