Are There Survival Differences Between Women with Equivalent Residual Disease After Interval Cytoreductive Surgery Compared with Primary Cytoreductive Surgery for Advanced Ovarian and Peritoneal Cancer?

Autor:	David Pierce, Mysona, Sharad, Ghamande, Jin-Xiong, She, Lynn, Tran, Paul, Tran, Bunja J, Rungruang, John K, Chan, Victoria, Bae-Jump, Paola A, Gehrig
Rok vydání:	2020
Předmět:	Ovarian Neoplasms Neoplasm Residual Chemotherapy Adjuvant Humans Female Cytoreduction Surgical Procedures Neoplasms Glandular and Epithelial Neoadjuvant Therapy Peritoneal Neoplasms Neoplasm Staging Retrospective Studies
Zdroj:	Annals of surgical oncology. 28(7)
ISSN:	1534-4681
Popis:	The aim of this study was to investigate survival differences between equivalent residual disease [complete gross resection (CGR), minimal residual disease (MRD), suboptimal] at the time of primary debulking surgery (PDS) and interval debulking surgery (IDS).The National Cancer Database was used to identify patients from 2010 to 2015 with stage IIIC/IV primary peritoneal or ovarian cancer who had residual disease recorded. Propensity score matching (PSM) was used to correct for differences in characteristics between the PDS and IDS groups.Of 8683 patients with advanced ovarian cancer, 4493 (52%), 2546 (29%), and 1644 (19%) had CGR, MRD, or suboptimal resection, respectively. From 2010 to 2015, the number of patients undergoing IDS increased 27% (pThe use of IDS continues to rise in the US, and is associated with improved surgical outcomes but not necessarily similar oncologic outcomes. There should be continued efforts to improve cytoreductive outcomes in women with advanced ovarian and peritoneal malignancies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c14b2fa2c26c8aa1a9f72d671cb7698f https://pubmed.ncbi.nlm.nih.gov/33155151 Zobrazit plný text záznamu Full text from SpringerLink