| Popis: |
To study the evolution of chronic hepatitis in HIV-HCV co-infected patients and the factors conditioning this evolution.55 intravenous drug users with HIV-HCV co-infection were studied. We performed a clinical and laboratory study determining the age at the time of HCV infection and the date of liver biopsy, HIV stage, CD4 cell count, viral load, and time under antiretroviral treatment. Moreover, we analyzed the HCV genotype, HCV viral load, ALT plasmatic level, and liver biopsy. Univariate and multivariate analyses were made.55 patients with HIV-HCV co-infection were evaluated. In the multivariate analysis, gender (p = 0.034; 95% confidence interval [CI], 1.306-1082.625), lowest level of CD4+ lymphocytes (p = 0.021; 95% CI, 1,693-653,484) and highest viral load value (p = 0.022; 95% CI, 1366-53,817) were significantly correlated with liver disease progression.Both a male sex and a poor immune system situation are associated with a worse evolution of chronic hepatitis C. |
