Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene
| Autor: | M, Amin, H H, Uhlig, M, Kamprad, J, Karbe, A A, Osman, F, Grahmann, H, Hummelsheim, T, Mothes |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Huntingtin Protein
Nuclear Proteins Proteins Muscle Smooth Nerve Tissue Proteins Autoantigens Brain Ischemia Immunoglobulin A Autoimmune Diseases of the Nervous System Genes Microscopy Fluorescence Cerebellum Sequence Homology Nucleic Acid Intestine Small Humans Schwann Cells Chromosomes Human Pair 4 Intestinal Mucosa Nervous System Diseases Myelin Sheath Autoantibodies Gene Library |
| Zdroj: | Scandinavian journal of immunology. 53(2) |
| ISSN: | 0300-9475 |
| Popis: | Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|