| Autor: |
Michael B, Sano, Christopher C, Fesmire, Ross A, Petrella |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Annals of biomedical engineering. 49(1) |
| ISSN: |
1573-9686 |
| Popis: |
Thermal tissue injury is an unintended consequence in current irreversible electroporation treatments due to the induction of Joule heating during the delivery of high voltage pulsed electric fields. In this study active temperature control measures including internal electrode cooling and dynamic energy delivery were investigated as a process for mitigating thermal injury during treatment. Ex vivo liver was used to examine the extent of thermal injury induced by 5000 V treatments with delivery rates up to five times faster than current clinical practice. Active internal cooling of the electrode resulted in a 36% decrease in peak temperature vs. non-cooled control treatments. A temperature based feedback algorithm (electro-thermal therapy) was demonstrated as capable of maintaining steady state tissue temperatures between 30 and 80 °C with and without internal electrode cooling. Thermal injury volumes of 2.6 cm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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