| Autor: |
H, Schilling, N, Bornfeld, S, Talies, G, Anastassiou, A, Schüler, G A, Horstmann, B, Jurklies |
| Jazyk: |
němčina |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Klinische Monatsblatter fur Augenheilkunde. 223(6) |
| ISSN: |
0023-2165 |
| Popis: |
The aim of this non-comparative, consecutive case series is to evaluate the short-term results after endoresection of large uveal melanomas in combination with pretreatment with stereotactic gamma knife radiosurgery.Between March 2000 and November 2002, forty-six patients with large uveal melanomas underwent stereotactic radiosurgery followed by endoresection of the tumour via a standard three-port vitrectomy including laser photocoagulation and silicone oil tamponade. The average tumour height was 9.5 mm. The minimum dose delivered to the tumour volume was 25 Gy.The median follow-up time was 410 days. In 40 cases (87 %), the eye was retained with a VA of 20/200 or better in 30 cases (65.2 %) and 20/63 or better in ten cases (21.7 %). In 12 eyes with a follow-up of/= 0.5 years, the median VA was 20/80 after silicone oil removal and cataract surgery had been performed. Six eyes (13 %) were enucleated due to serious complications caused by the radiosurgery (3 cases) or endoresection (3 cases). In 13 patients (28.2 %), additional major surgery was required. Seven patients developed liver metastases during follow-up and six patients died. No local tumour recurrences were observed.Eyes with large uveal melanomas can be salvaged by stereotactic radiotherapy followed by endoresection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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