Assessment of serum-mediated neurotoxicity in Navajo neuropathy
| Autor: | M W, Lawlor, S, Holve, E B, Stubbs |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Muscle Weakness
Electromyography Liver Diseases Arizona Neural Conduction Paraproteinemias Peripheral Nervous System Diseases Evoked Potentials Motor Rats Ganglia Spinal Sensation Disorders Indians North American Neurites Animals Humans Neurons Afferent Motor Neuron Disease Sciatic Neuropathy Child Corneal Ulcer |
| Zdroj: | Electromyography and clinical neurophysiology. 40(4) |
| ISSN: | 0301-150X |
| Popis: | Navajo neuropathy is a unique sensorimotor neuropathy which is geographically restricted to Navajo children living on the Navajo Reservation. Affected patients present with weakness, loss of sensation in extremities, corneal ulcerations, and a high incidence of childhood infections. Metabolic complications, such as severe liver disease, may further contribute to peripheral nerve injury in affected patients. In this study, serum-mediated injury to rat peripheral nerve was critically assessed. Serum samples from affected Navajo patients were tested in vivo for effects on peripheral nerve function. Injection of serum from affected Navajo patients into rat sciatic nerve produced a modest slowing of nerve conduction velocity without effecting evoked-compound muscle action potential (CMAP) amplitudes. By comparison, injection of serum from patients with MGUS neuropathy, an immune-mediated disorder, diminished evoked-CMAP amplitudes by approximately 70%. Navajo neuropathy sera had no effect in vitro on the neurite outgrowth of developing dorsal root ganglia neurons. The results argue against serum-mediated toxic injury to peripheral nerves in Navajo neuropathy. |
| Databáze: | OpenAIRE |
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