| Autor: |
Xue-Liang, Zuo, Zhi-Qiang, Chen, Jun-Feng, Wang, Jin-Guo, Wang, Lin-Hu, Liang, Juan, Cai |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
American journal of cancer research. 8(4) |
| ISSN: |
2156-6976 |
| Popis: |
Accumulating evidence has indicated that microRNA (miRNA) dysregulation contributes to hepatocellular carcinoma (HCC) progression. miR-337-3p is downregulated in gastric cancer and neuroblastoma; however, its biological function and underlying mechanism in HCC remain unclear. In this study, we showed that the expression level of miR-337-3p was significantly decreased in HCC, and was associated with several clinicopathological characteristics, including tumor multiplicity, histological differentiation, and Barcelona Clinic Liver Cancer stage. Low expression level of miR-337-3p was associated with poor survival outcomes in HCC patients. Upregulation of miR-337-3p suppressed cell proliferation, migration, and invasion in HCC. Dual luciferase assay demonstrated that JAK2 was a direct downstream target of miR-337-3p. JAK2 reintroduction restored the inhibited proliferation, migration, and invasion of miR-337-3p overexpressed HCC cells. miR-337-3p functioned as a tumor suppressor to modulate the JAK2/STAT3 signaling pathway. The present findings indicate that miR-337-3p could be used as a prognostic predictor and therapeutic candidate for HCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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