An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of
| Autor: | Chloe Y Y, Cheung, Clara S, Tang, Aimin, Xu, Chi-Ho, Lee, Ka-Wing, Au, Lin, Xu, Carol H Y, Fong, Kelvin H M, Kwok, Wing-Sun, Chow, Yu-Cho, Woo, Michele M A, Yuen, Stacey S, Cherny, JoJo, Hai, Bernard M Y, Cheung, Kathryn C B, Tan, Tai-Hing, Lam, Hung-Fat, Tse, Pak-Chung, Sham, Karen S L, Lam |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Carnitine O-Palmitoyltransferase Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Fatty Acids Mutation Missense Glucose-6-Phosphate Middle Aged Polymorphism Single Nucleotide Fibroblast Growth Factors Malonyl Coenzyme A Asian People Gene Expression Regulation Glucokinase Humans Exome Female Adaptor Proteins Signal Transducing Aged |
| Zdroj: | Diabetes. 66(6) |
| ISSN: | 1939-327X |
| Popis: | Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and two clinic-based cohorts. A custom Asian exome-chip was used to detect genetic determinants influencing circulating FGF21 levels. Single-variant association analysis interrogating 70,444 single nucleotide polymorphisms identified a novel locus |
| Databáze: | OpenAIRE |
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