| Autor: |
M C, Deng, J M, De Meester, J M, Smits, J, Heinecke, H H, Scheld |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
BMJ (Clinical research ed.). 321(7260) |
| ISSN: |
0959-8138 |
| Popis: |
To determine whether there is a survival benefit associated with cardiac transplantation in Germany.Prospective observational cohort study.All 889 adult patients listed for a first heart transplant in Germany in 1997.Mortality, stratified by heart failure severity.Within 1 year after listing, patients with a predicted high risk had the highest global death rate (51% v 32% and 29% for medium and low risk patients respectively; P0.0001), had the highest risk of dying on the waiting list (32% v 20% and 20%; P=0.0003), and were more likely to receive a transplant (48% v 45% and 41%; P=0.01). Differences between the risk groups in outcome after transplantation did not reach significance (P=0.2). Transplantation was not associated with a reduction in mortality risk for the total cohort, but it did provide a survival benefit for the high risk group.Cardiac transplantation in Germany is currently associated with a survival benefit only in patients with a predicted high risk of dying on the waiting list. Patients with a predicted low or medium risk have no reduction in mortality risk associated with transplantation; they should be managed with organ saving approaches rather than transplantation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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