Proteolytic activity in patients with hypercatabolic renal failure

Autor: W H, Hörl, R M, Schäfer, K, Scheidhauer, M, Jochum, A, Heidland
Rok vydání: 1984
Předmět:
Zdroj: Advances in experimental medicine and biology. 167
ISSN: 0065-2598
Popis: Proteolytic enzymes exist in ultrafiltrated plasma, concentrated dialysates and urine fractions of patients with posttraumatic renal failure. Differences in digestion pattern of phosphorylase kinase suggest the existence of different proteases in patients with hypercatabolic renal failure. Trypsin binding capacity is reduced in RDT patients and markedly lower in patients with posttraumatic ARF. Protein catabolism is inhibited in vitro by alpha 2-macroglobulin. From our in vitro studies we favour the application of fresh frozen plasma instead of the available plasma protein solutions to hypercatabolic patients. Hemodialysis may enhance proteinase inhibitory capacity of the plasma. Hemodialysis therapy induces the increase of plasma E-X1 PI. The continuous release of granulocyte elastase during hemodialysis therapy may enhance the risk for the development of destructive lung disease.
Databáze: OpenAIRE
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