| Autor: |
Peter, Libby, Robert, Sidlow, Amy E, Lin, Dipti, Gupta, Lee W, Jones, Javid, Moslehi, Andreas, Zeiher, Siddhartha, Jaiswal, Christian, Schulz, Ron, Blankstein, Kelly L, Bolton, David, Steensma, Ross L, Levine, Benjamin L, Ebert |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
J Am Coll Cardiol |
| ISSN: |
1558-3597 |
| Popis: |
A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in hematopoietic stem cells that yield clonal progeny of mutant leukocytes in blood. Individuals with CHIP have a doubled risk of coronary heart disease and ischemic stroke, and worsened heart failure outcomes independent of traditional cardiovascular risk factors. The recognition of CHIP as a non-traditional risk factor challenges specialists in hematology/oncology and cardiovascular medicine alike. Should we screen for CHIP? If so, in whom? How should we assess cardiovascular risk in people with CHIP? How do we manage the excess cardiovascular risk in the absence of an evidence base to guide us? This document explains CHIP, explores the clinical quandaries, strives to provide reasonable recommendations for the multidisciplinary management of cardiovascular risk in individuals with CHIP, and highlights current knowledge gaps. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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