Perftoran as a means modulating the functional activity of liver macrophages

Autor:	A Yu, Kovelenov, A N, Mikhal'tsov, A N, Malkov
Rok vydání:	2002
Předmět:	Lethal Dose 50 Fluorocarbons Mice Liver Phagocytosis Blood Substitutes Kupffer Cells Animals Alanine Transaminase Chemical and Drug Induced Liver Injury Coloring Agents Carbon
Zdroj:	Bulletin of experimental biology and medicine. 134(6)
ISSN:	0007-4888
Popis:	Experiments on mice showed that perfluorocarbon emulsion Perftoran modulated phagocytic activity of liver macrophages (evaluated by LD50 for Salmonella typhi endotoxin and the rate of elimination of Chinese ink particles from the bloodflow). Phagocytic activity was suppressed for 3 days after injection of 10 mg/kg emulsion, but then increased above the control. Perftoran had a favorable impact on the course of experimental hepatitis in a model experiment based on hyperactivity of Kupffer cells. Perftoran virtually prevented the development of severe hepatitis after prophylactic injection and notably attenuated hepatocyte cytolysis when used as therapeutic mean.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bfc40257d404aea868746524a1bad142 https://pubmed.ncbi.nlm.nih.gov/12660835 Zobrazit plný text záznamu Full text from SpringerLink