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Intestinal microflora was investigated by fecal bacteriological examination in 175 patients with verified rheumatoid arthritis (RA). Intestinal dysbacteriosis of different stages was detected in 75% of the RA patients on nonsteroid antiinflammatory treatment. The frequency and severity of abnormal biocenosis in RA patients were significantly greater than in subjects with osteoarthritis deformans (p0.01) and bronchial asthma patients (p0.01). Dysbacteriosis severity increased with growing RA activity (between the groups with the activity stage I and III the difference was significant, p( 0.05). After the fecal microorganisms inoculation it became evident that RA patients carry, as a rule, Clostridium perfringens. Seven RA patients diagnosed to have dysbacteriosis received adjuvant bactisubtil (dry culture of the strain Bacillus IP 5832). The addition of bactisubtil aggravated the patients' condition, in 4 patients, moreover, the microflora got worse. Explanations of the observations on the direct participation of the intestine in RA pathogenesis are suggested. |
