| Autor: |
V L, Andronova, A A, Pchelintseva, A V, Ustinov, A L, Petrunina, V A, Korshun, M V, Skorobogatyĭ, G A, Galegov |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Voprosy virusologii. 51(1) |
| ISSN: |
0507-4088 |
| Popis: |
A series of new 5-alkynyl-2'-deoxyuridines have been synthesized and their antiherpetic activity was tested in the cultured Vero cells on a model of herpes simplex virus type 1, including its acyclovir-resistant strains. Some test compounds were found to have a significant specific antiherpetic activity. Nucleoside XIV showed the greatest activity. Compounds IV and X also has displayed a significant activity against the herpes simplex virus type 1 strain that is highly resistant to acyclovir. Examining the combined action of substance II with acyclovir and ganciclovir has revealed a synergetic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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