Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation
| Autor: | Tao, Peng, Xiaoyan, Liu, Jingtao, Wang, Yu, Liu, Zhenqiang, Fu, Xingrong, Ma, Junmin, Li, Guifang, Sun, Yangfei, Ji, Jingjing, Lu, Wencui, Wan, Hong, Lu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
TOR Serine-Threonine Kinases Vesicular Transport Proteins Autophagy-Related Proteins Apoptosis Parkinson Disease Mice Inbred C57BL Mice MicroRNAs Phosphatidylinositol 3-Kinases Gene Expression Regulation Cell Line Tumor Autophagy Animals Humans RNA Long Noncoding Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Artificial cells, nanomedicine, and biotechnology. 47(1) |
| ISSN: | 2169-141X |
| Popis: | Parkinson's disease (PD) is a common age-related neurodegenerative disease resulted from the progressive degeneration of dopaminergic neurons in the pars compacta region of substantia nigra. The goal of this study was to investigate the effects and mechanisms of long noncoding RNA (lncRNA) HAGLROS on the apoptosis and autophagy in PD. The MPTP-induced PD mouse model and MPP |
| Databáze: | OpenAIRE |
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