TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues

Autor:	T, Nakabayashi, K M, Sakata, A, Sakata, L, Kong, C A, Lau, J J, Letterio, N, Vela-Roch, N, Talal, H, Dang
Rok vydání:	2001
Předmět:	Inflammation Mice Knockout Myocardium T-Lymphocytes CD40 Ligand Autoimmunity Lymphocyte Activation Immunohistochemistry Interleukin-12 Salivary Glands Up-Regulation Mice Inbred C57BL Mice Liver Transforming Growth Factor beta Animals Tissue Distribution RNA Messenger Lung
Zdroj:	Inflammation. 25(2)
ISSN:	0360-3997
Popis:	The TGF-beta1(-/-) mouse is a murine model for systemic autoimmune disease. The aim of this study is to elucidate the immunological mechanism that leads to multifocal tissue inflammation and autoantibody production in TGF-beta1(-/-) mice. Heart, lung, liver, and salivary gland from TGF-beta1(-/-) were assessed for CD154 expression by RT-PCR and immunohistochemistry. Compared to wild-type littermates, CD154 expression was elevated in all tissues studied. Furthermore, IL-12 mRNA was expressed in the salivary gland and heart of TGF-beta1(-/-) mice and not in wild-type littermates. This suggests that the CD154 pathway is activated in these tissues. This shows that TGF-beta1 regulates CD154 expression leading to spontaneous IL-12 production and autoimmunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bf705510d281b5771f00555435828b71 https://pubmed.ncbi.nlm.nih.gov/11321361 Zobrazit plný text záznamu Full text from SpringerLink