Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

Autor:	J H, Kordower, S, Palfi, E Y, Chen, S Y, Ma, T, Sendera, E J, Cochran, E J, Mufson, R, Penn, C G, Goetz, C D, Comella
Rok vydání:	1999
Předmět:	Immunoenzyme Techniques Male Neuroprotective Agents Brain Humans Nerve Tissue Proteins Parkinson Disease Glial Cell Line-Derived Neurotrophic Factor Nerve Growth Factors Aged Injections Intraventricular
Zdroj:	Annals of neurology. 46(3)
ISSN:	0364-5134
Popis:	As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bf6796928a20c37134a684107683b305 https://pubmed.ncbi.nlm.nih.gov/10482276 Zobrazit plný text záznamu Plný text