A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats
| Autor: | Jeff C, Ko, Lisa A, Abbo, Ann B, Weil, Brenda M, Johnson, Mark, Payton |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Narcotics Xylazine Anesthetics Dissociative Tiletamine Cross-Over Studies Time Factors Respiration Imidazoles Blood Pressure Medetomidine Zolazepam Glycopyrrolate Injections Intramuscular Anesthetics Combined Treatment Outcome Butorphanol Heart Rate Cats Animals Anesthesia Female Adrenergic alpha-Agonists Adrenergic alpha-Antagonists Adjuvants Anesthesia |
| Zdroj: | Veterinary therapeutics : research in applied veterinary medicine. 8(3) |
| ISSN: | 1528-3593 |
| Popis: | Using a randomized crossover design, this study compared the anesthetic and cardiorespiratory effects of three intramuscular anesthetic combinations in seven 2-year-old cats: tiletamine-zolazepam (8 mg/kg) and butorphanol (0.2 mg/kg) (TT); tiletamine-zolazepam (3 mg/kg), butorphanol (0.15 mg/kg), and medetomidine (15 microg/kg) (TTD); or the TTD protocol plus atipamezole (75 microg/kg IM) given 20 minutes later to reverse medetomidine. Analgesia was assessed using algometry and needle pricking. All three combinations effectively induced anesthesia suitable for orotracheal intubation within 5 minutes after injection. Hemoglobin oxygen saturation was lower than 90% at least once in all three groups between 5 and 15 minutes after drug administration. Blood pressure and heart and respiratory rates were within normal ranges. Both TT and TTD appeared to be effective injectable anesthetic combinations. TTD provided significantly better analgesia with a longer duration than did TT. Atipamezole administration shortened the duration of analgesia and decreased blood pressure but did not shorten total recovery time. |
| Databáze: | OpenAIRE |
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