| Autor: |
C M, Kraan, D R, Hocking, J L, Bradshaw, N, Georgiou-Karistianis, S A, Metcalfe, A D, Archibald, J, Fielding, J, Trollor, J, Cohen, K M, Cornish |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Genes, brain, and behavior. 13(4) |
| ISSN: |
1601-183X |
| Popis: |
This study examines implicit sequence learning impairments that may indicate at-risk cerebellar profiles proposed to underlie some aspects of subtle cognitive and affective dysfunctions found among female fragile X mental retardation 1 (FMR1) premutation (PM)-carriers. A total of 34 female PM-carriers and 33 age- and intelligence-matched controls completed an implicit symbolically primed serial reaction time task (SRTT) previously shown to be sensitive to cerebellar involvement. Implicit learning scores indicated a preservation of learning in both groups; however, PM-carriers demonstrated poorer learning through significantly elevated response latencies overall and at each specific block within the symbolic SRTT. Group comparisons also revealed a core deficit in response inhibition, alongside elevated inattentive symptoms in female PM-carriers. Finally, strong and significant associations were observed between poor symbolic SRTT performance and executive, visuospatial and affective deficits in the PM-carrier group. These associations remained strong even after controlling motor speed, and were not observed in age- and intelligence quotient-matched participants. The findings implicate cerebellar non-motor networks subserving the implicit sequencing of responses in cognitive-affective phenotypes previously observed in female PM-carriers. We contend that symbolic SRTT performance may offer clinical utility in future pharmaceutical interventions in female PM-carriers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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