Comparative study of lipid composition and proliferative activity of rat cholangiocarcinoma RS1 and sarcoma M1 depending on the transplantation organ

Autor:	V A, Kobliakov, O G, Somova, A G, Kandyba, V F, Kondalenko, N M, Klim, E V, Dyatlovitskaya
Rok vydání:	2002
Předmět:	Cholangiocarcinoma Liver Neoplasms Experimental Gangliosides Mitotic Index Animals Sarcoma Experimental Lipid Metabolism Lipids Cell Division Neoplasm Transplantation Phospholipids Rats
Zdroj:	Biochemistry. Biokhimiia. 67(11)
ISSN:	0006-2979
Popis:	The proliferative activity and lipid composition (phospholipids, gangliosides) were studied in rat cholangiocarcinoma RS1 and sarcoma M1 transplanted subcutaneously or intrahepatically. The mitotic index was higher in the tumors transplanted into the heterologous organ. The total phospholipid and sphingomyelin contents were higher in the tumors transplanted intrahepatically. GM3 and GD3 were the main gangliosides in both variants of each tumor. A significant amount of GM3 ganglioside lactone was found in the intrahepatic variants whereas it was absent in the subcutaneous tumors. Both the mitotic index and lipid composition of the tumors studied depended on their microenvironment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bf38519bb0903842c2a3c8b56331cc3c https://pubmed.ncbi.nlm.nih.gov/12495423 Zobrazit plný text záznamu Full text from SpringerLink