| Autor: |
Lothar, Weissfloch, Michael, Peller, Juergen, Weber, Hans-Juergen, Feldmann, Reingart, Senekowitsch-Schmidtke, Karlheinz, Tempel, Jeffrey A, Coderre, Michael, Molls, Michael, Reiser |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Advances in experimental medicine and biology. 530 |
| ISSN: |
0065-2598 |
| Popis: |
The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
