| Autor: |
Chaicharn, Deerochanawong, Peera, Buranakitjaroen, Wannee, Nitiyanant, Jithanorm, Suwantamee, Chumpol, Piamsomboon, Varaphon, Vongthavaravat, Nijasri Charnnarong, Suwanwela, Natapong, Kosachunhanun, Apichard, Sukonthasarn |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 90(1) |
| ISSN: |
0125-2208 |
| Popis: |
To evaluate the efficacy and safety of atorvastatin at the starting doses of 10, 20, 40 mg and evaluate the effectiveness of 1 step titrate up regimen.Two hundred and forty two subjects with dyslipidemia were enrolled and assigned the appropriate dose in relation to their individual cardiovascular risk status and baseline LDL-C levels. If the NCEP targets were not achieved, the doses were titrated up at week 4 and the primary efficacy was evaluated at week 8.A majority of subjects (88.8%) achieved their LDL-C goals at week 8. Almost all of the subject's LDL-C levels reached their goals by week 2 and 4 (81.6% and 87.1%, respectively). Only 10.7% (n = 25) required the sole titration. Each dose provided significant decreases in LDL-C (average -46.4%). Only 36 subjects experienced treatment related adverse events, the majority of these were in the high-risk group (n = 22) with only one subject registering a serious adverse event.Atorvastatin is effective and safe for Thai patients with dyslipidemia. The appropriate starting dose has contributed in the achievement of cholesterol reduction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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