| Autor: |
Takeo, Hara, Yuta, Kasagi, Joshua, Wang, Masaru, Sasaki, Bailey, Aaron, Adam, Karami, Masataka, Shimonosono, Rieko, Shimonosono, Hisatsugu, Maekawa, Lauren, Dolinsky, Benjamin, Wilkins, Jeremy, Klein, Jane, Wei, Kathryn, Nunes, Kristle, Lynch, Jonathan M, Spergel, Kathryn E, Hamilton, Melanie A, Ruffner, Tatiana A, Karakasheva, Kelly A, Whelan, Hiroshi, Nakagawa, Amanda B, Muir |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cellular and molecular gastroenterology and hepatology. 13(5) |
| ISSN: |
2352-345X |
| Popis: |
Although basal cell hyperplasia is a histologic hallmark of eosinophilic esophagitis (EoE), little is known about the capabilities of epithelial renewal and differentiation in the EoE inflammatory milieu. In murine esophageal epithelium, there are self-renewing and slowly proliferating basal stem-like cells characterized by concurrent expression of CD73 (5'-nucleotidase ecto) and CD104 (integrin β4). Here, we investigated CD73We performed flow cytometry on esophageal biopsy samples from EoE and non-EoE patients to determine the quantity of CD73EoE patients showed decreased epithelial CD73This study addressed the role of CD73 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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