| Autor: |
F S, Chiccarelli, J A, Morrison, D B, Cosulich, N A, Perkinson, D N, Ridge, F W, Sum, K C, Murdock, D L, Woodward, E T, Arnold |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Cancer research. 46(9) |
| ISSN: |
0008-5472 |
| Popis: |
Two polar metabolites of mitoxantrone, a clinically active antitumor agent, have been isolated and purified from the urine of patients by sequential absorption on glass wool and C18-Sep-Pak cartridges followed by preparative high-performance liquid chromatography. Negative ion chemical ionization mass spectrometry indicated that the two metabolites are the di- and mono-carboxylic acids resulting from oxidation of the terminal hydroxyl groups of the side chain(s). Mass spectral comparison of the urinary metabolites with synthetic compounds confirmed the identification. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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