The Māori and Pacific specific CREBRF variant and adult height

Autor:	Louise K, Metcalfe, Mohanraj, Krishnan, Nigel, Turner, Hanieh, Yaghootkar, Troy L, Merry, Ofa, Dewes, Jennie Harré, Hindmarsh, Janak, De Zoysa, Nicola, Dalbeth, Lisa K, Stamp, Tony R, Merriman, Greg, Smith, Peter, Shepherd, Rinki, Murphy
Rok vydání:	2019
Předmět:	Adult Male Native Hawaiian or Other Pacific Islander Tumor Suppressor Proteins Mutation Missense Mice Transgenic Body Height Cohort Studies Mice Animals Humans Female Gene Knock-In Techniques Alleles New Zealand
Zdroj:	International journal of obesity (2005). 44(3)
ISSN:	1476-5497
Popis:	The CREBRF missense variant (p.Arg457Gln) is paradoxically associated with lower risk of type 2 diabetes, yet higher body mass index (BMI). Here we sought to determine whether this CREBRF variant might be associated with adult height.Linear regression was used to analyse the association of the CREBRF minor (A) allele with height in 2286 Māori and Pacific adults living in Aotearoa/New Zealand. A potential type 2 diabetes index event was corrected to account for a bias that may be the cause of paradoxical association between the CREBRF diabetes-protective allele and higher BMI and height.The CREBRF protective allele was associated with increased adult height (ß = 1.25 cm, P = 3.9 × 10These data taken together indicate that CREBRF p.Arg457Gln is associated with taller stature in Māori and Pacific adults.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bec201abdd328490788e8ac5c1a16c8a https://pubmed.ncbi.nlm.nih.gov/31543511 Zobrazit plný text záznamu Full text from SpringerLink