High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol

Autor:	S A, Poulsen, D J, Young, R J, Quinn
Rok vydání:	2001
Předmět:	Pyrimidines Cell Membrane Pressure Purinergic P1 Receptor Agonists Receptors Purinergic P1 Animals Pyrazoles Stereoisomerism Binding Competitive Basal Ganglia Protein Binding Rats
Zdroj:	Bioorganicmedicinal chemistry letters. 11(2)
ISSN:	0960-894X
Popis:	The synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines has been performed by aromatic nucleophilic substitution of 4-amino-6-chloro-1-phenylpyrazolo[3,4-rd]pyrimidine under conditions of high pressure at ambient temperature. Conventional synthetic conditions (reflux at atmospheric pressure) were unsuccessful. The S enantiomer 11 displayed higher affinity and selectivity for the adenosine A1 receptor than the R enantiomer 12.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bea33627f9eff7f3fa345651b0ef8770 https://pubmed.ncbi.nlm.nih.gov/11206456 Zobrazit plný text záznamu Full Text from ScienceDirect