| Autor: |
Nogami-Hara, Ai, Kubota, Kaori, Takasaki, Kotaro, Watanabe, Takuya, Iba, Hikari, Fujikawa, Risako, Katsurabayashi, Shutaro, Iwasaki, Katsunori, Egahira, Nobuaki, Bolukbasi Hatip, Funda, Hatip-Al-Khatib, Izzettin |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 39(1) |
| ISSN: |
2589-451X |
| Popis: |
To examine the effects of Yokukansan (YKS) extract on two endogenous modulators of anxiety, brain-derived neurotrophic factor (BDNF) and serotonin (5-HT)2A receptors pharmacologically, in the ischemic rat model of dementia.The cerebral ischemia (CI) was induced by bilateral occlusion of the vertebral and common carotid arteries (4-vessel occlusion ischemia). The CI was combined with the amyloid-β42 peptide (Aβ42) injected intracerebroventricularly, and referred to as CI+Aβ. Anxiety-like behaviors were assessed by elevated plus maze (enclosed arm), light/dark transition test (dark chamber), and open-field test. Wet-dog shakes were induced by the 5-HT2A receptor agonist 2, 5-dimethoxy-4-iodoamphetamine (DOI). The concentration of BDNF in serum was determined by enzyme-linked immuno sorbent assay.CI + Aβ increased anxiety, as demonstrated by the increase of time spent in the enclosed arms and dark chambers, and locomotion in the outer zone of the open field (thigmotaxis). CI + Aβ decreased the serum concentration of BDNF. YKS reduced the anxiety-like behaviors, suppressed the DOI-induced wet-dog shakes and increased serum BDNF concentrations.Our findings suggest that YKS extract improves CI + Aβ-induced anxiety by antagonizing 5-HT2A receptors and increasing BDNF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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