| Autor: |
Ayôla A, Adegnika, Lutz Ph, Breitling, Selidji T, Agnandji, Sanders K, Chai, Daniela, Schütte, Sunny, Oyakhirome, Norbert G, Schwarz, Martin P, Grobusch, Michel A, Missinou, Michael, Ramharter, Saadou, Issifou, Peter G, Kremsner |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
The American journal of tropical medicine and hygiene. 73(2) |
| ISSN: |
0002-9637 |
| Popis: |
Pregnant women participating in a longitudinal immuno-epidemiologic survey in Lambaréné, Gabon, and presenting with Plasmodium falciparum parasitemia at monthly blood smear examinations were offered treatment with oral 7-day quinine monotherapy according to national health guidelines. A total of 50 pregnant women were offered 7-day oral quinine sulfate 10 mg/kg thrice daily. Clinical examinations and laboratory tests were performed on Days 28 and 56 to assess the effectiveness of this standard regimen. By Day 28, the effectiveness of the 7-day quinine regimen was 60% (95% confidence interval: 46-72%). We conclude that a 7-day course of quinine has a poor effectiveness and that alternative treatment regimens for malaria in pregnant women should be assessed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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