Immunogenicity of a new Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate) (PedvaxHIB)
| Autor: | P P, Vella, J M, Staub, J, Armstrong, K T, Dolan, C M, Rusk, S, Szymanski, W E, Greer, S, Marburg, P J, Kniskern, T L, Schofield |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Mice Inbred BALB C Haemophilus Infections Diphtheria Toxoid T-Lymphocytes Polysaccharides Bacterial Mice Nude Neisseria meningitidis Antibodies Bacterial Haemophilus influenzae Macaca mulatta Rats Mice Rats Inbred SHR Bacterial Vaccines Animals Female Bacterial Outer Membrane Proteins Haemophilus Vaccines |
| Zdroj: | Pediatrics. 85(4 Pt 2) |
| ISSN: | 0031-4005 |
| Popis: | Haemophilus influenzae type b is responsible for an estimated 15,000 to 20,000 cases of meningitis per year in the United States, mainly in children 2 months to 5 years old. The mortality rate from meningitis due to H influenzae type b infections ranges from 5% to 10%. Despite antibiotic treatment, up to 35% of survivors have permanent neurologic sequelae. In addition to meningitis, H. influenzae type b is responsible for other invasive infections, including epiglottitis, septicemia, cellulitis, septic arthritis, osteomyelitis, pneumonia, pericarditis, and otitis media; approximately 30,000 cases H influenzae diseases occur annually in the United States. The diseases peak in incidence between 6 and 12 months of age, with almost one half of the cases occurring before 1 year of age. About 75% of disease caused by H influenzae type b occurs in children younger than 24 months old. The incidence of disease is higher in children of certain groups, including blacks, Hispanics, Eskimos and Native Americans, young children attending day-care facilities, patients with asplenia or antibody-deficiency syndromes, and children of lower socioeconomic status. There is considerable evidence that antibody to the capsular polysaccharide (polyribosylribitol-phosphate [PRP] of H influenzae type b is protective.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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