Transfection of chronic lymphocytic leukemic cells with myc and ras

Autor:	C Y, Zheng, L F, Skinnider, J, Xian, A, Maksymiuk
Rok vydání:	1992
Předmět:	Cell Transformation Neoplastic Genes ras Phenotype Karyotyping Genes myc Tumor Cells Cultured Humans Transfection Leukemia Lymphocytic Chronic B-Cell
Zdroj:	Leukemia. 6
ISSN:	0887-6924
Popis:	Thirty samples of cells from twenty-one cases of chronic lymphocytic leukemia (CLL) were transfected with myc and/or ras. Transformation, as assessed by growth in liquid culture and change in morphology, occurred in only one case. Colony culture in semi-solid media, however, does not occur with these cells. It would appear that the neoplastic genotype of CLL cells does not predispose the cells to readily transform, even with transfection with these two oncogenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::be629eeef149c768d42986354a1aba5f https://pubmed.ncbi.nlm.nih.gov/1602824 Zobrazit plný text záznamu