| Autor: |
Zurab, Kuchukashvili, George, Burjanadze, Ketevan, Menabde, Matrona, Chachua, Natalia, Dachanidze, Mariam, Mikadze, Nana, Koshoridze |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Acta neurobiologiae experimentalis. 72(1) |
| ISSN: |
1689-0035 |
| Popis: |
We have studied biochemical changes occurring in brain cell mitochondria of white rats on the background of stress induced by 30-day isolation and disruption of circadian rhythms. It was ascertained that due to long-lasting stress, there occurs activation of oxidative processes in mitochondria as well as inhibition of anti-oxidant system activity, causing development of energy deficiency in brain cells. The above-mentioned biochemical processes become the reason for activation and opening of the mitochondrial permeability transition pore (MPTP), which, in its turn, signals the start of neuroapoptosis and various neurodegenerative processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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