| Autor: |
E E, Leenman, M S, Mukhina, M M, Girshovich, S V, Kanaev, S N, Konoplev, K M, Pozharisskiĭ |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Arkhiv patologii. 72(2) |
| ISSN: |
0004-1955 |
| Popis: |
Dendritic cells (DCs) are the least studied microenvironment elements in Hodgkin's lymphoma (HL). Ninety-five lymph nodes were morphologically and immunohistochemically studied in patients with classical HL. The authors found CDla- and langerin-positive DCs in the presence of T lymphocytes, which were localized in the close proximity to neoplastic Reed-Sternberg cells (RSCs). There were also CD23-positive follicular DCs, which were typically located at the periphery of tumor foci, in the areas of residual follicular structures, were surrounded by B lymphocytes and were rarely associated with RSCs. There were two morphologically distinct groups among the CD 1a- and langerin-positive DCs; one had developed cytoplasmic processes, which formed a network around the RSCs (probably a more mature/functionally active form); the other had round cells with short cytoplasmic processes, loosely distributed around the neoplastic cells (a less mature/active form). The function and role of CD1a- and langerin-positive DCs in HL call for further investigation. The topographic closeness of these DCs to RSCs suggests that these cells play a considerable role in the pathogenesis of HL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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