[Efficacy of postoperative simple chemotherapy and concurrent chemoradiotherapy in FIGO stage IB2-IIB cervical cancer]
| Autor: | Ke, Ma, Yi-he, Yang, Xi, Yang, Zhao-Yi, Feng, Tong-yu, Liu, Hong-wu, Wen, Qin-ping, Liao |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Paclitaxel Uterine Cervical Neoplasms Chemoradiotherapy Adenocarcinoma Middle Aged Hysterectomy Disease-Free Survival Neoadjuvant Therapy Survival Rate Bleomycin Lymphatic Metastasis Antineoplastic Combined Chemotherapy Protocols Carcinoma Squamous Cell Humans Female Taxoids Ifosfamide Cisplatin Neoplasm Recurrence Local Follow-Up Studies Neoplasm Staging Retrospective Studies |
| Zdroj: | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 45(6) |
| ISSN: | 1671-167X |
| Popis: | To evaluate the effectiveness of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy plus postoperative chemotherapy but no radiotherapy for stage IB2-IIB cervical cancer.Seventy-nine patients with stage IB2-IIB cervical cancer were treated with NAC followed by radical hysterectomy. According to different adjuvant therapies, patients were divided into postoperative chemotherapy group (47 cases) and postoperative radiotherapy/concurrent chemoradiotherapy group (32 cases). Regimens for NAC and postoperative chemotherapy were BIP (bleomycin+ ifosfamide+ cisplatin/carboplatin) or TP (paclitaxel+ cisplatin/carboplatin). An average of 1.1±0.3 cycles of NAC and 3.4±1.2 cycles of postoperative chemotherapy were prescribed.Toxicities due to chemotherapy were generally tolerable. Overall response rate of NAC was 88.6%. With a median follow-up period of 42 months, the three-year progression-free survival rates of the two groups were 88.5% and 84.3%, the total survival rates were 90.3% and 86.4%, respectively. There was no statistically significant difference. The recurrent rates were 10.6% and 21.8% in the two groups. In the absence of radiotherapy, pelvic recurrence was observed in two patients; the other three had distant metastases.The results indicate that NAC followed by surgery plus postoperative chemotherapy but no radiotherapy offers a viable option in the treatment of stage IB2-IIB cervical cancer. The patients can tolerate the side effects of chemotherapy with better efficacy. |
| Databáze: | OpenAIRE |
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