| Autor: |
A, Gómez-Palacios, M A, Taibo, M T, Gutiérrez, P, Gómez, J, Gómez-Zabala, B, Barrios, A, Escobar, I, Iturburu |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Cirugia espanola. 79(2) |
| ISSN: |
0009-739X |
| Popis: |
The objectives of this study were: a) to evaluate the effectiveness of intraoperative intact parathyroid hormone (PTHi) determination as a marker of hyperparathyroidism resolution; b) to establish the minimum number of blood samples required; and c) to determine whether cervical manipulation increases baseline PTHi levels.We performed a prospective study in 45 patients. Three intraoperative blood PTHi determinations were performed: at baseline and at 10 and 25 minutes after excising the lesion. To analyze the effects of cervical manipulation, in 19 patients, 2 further determinations were made after 2 minutes of massage on both sides of the neck. A decrease of50% in PTHi values between postexeresis samples and the baseline sample (gradient50%) was used as diagnostic and therapeutic criteria and normalization of calcemia was used as a criteria for complete resolution.Whenever the lesion causing hyperparathyroidism was extirpated, PTHi levels decreased at 10 and 25 minutes after exeresis. This decrease was predictive of complete resolution when the gradient was50. Cervical manipulation (massage) did not increase PTHi values. In patients with complete resolution, blood calcium levels also returned to normal.1. Intraoperative PTHi determination with a gradient50 is an excellent prognostic marker of resolution. 2. Only 2 PTHi samples are required: one at baseline and another at 10 minutes after exeresis. 3. Preoperative cervical manipulation does not increase PTHi values. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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