| Autor: |
Muta M, Issa, Pei-Jung, Lin, Michael T, Eaddy, Manan B, Shah, E Anne, Davis |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
The American journal of managed care. 14(5 Suppl 2) |
| ISSN: |
1936-2692 |
| Popis: |
To evaluate the likelihood of alpha-adrenergic antagonist (alpha-blocker) discontinuation in combination with dutasteride or finasteride among patients agedor =65 years with enlarged prostate.This retrospective analysis used 2003-2006 data representing more than 30 million managed care members. Medical/pharmacy claims were used to select patients, matched 1:1 using propensity scoring. The proportion remaining on alpha-blocker therapy more than 12 months and time to discontinuation were compared between groups, controlling for covariates using survival analysis.The matched sample included 1674 patients. Alpha-blocker therapy discontinuation was observed at 90 days (86.9% dutasteride patients and 91.8% finasteride patients remained on alpha-blocker therapy). After 12 months, more dutasteride patients discontinued (38.1% remained) alpha-blocker therapy than finasteride patients (56.3% remained).Patients discontinued alpha-blocker therapy as early as 3 months. Those taking dutasteride were 64% more likely to discontinue alpha-blocker therapy than patients taking finasteride. Dutasteride's impact on discontinuation may have important implications and should be examined further. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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