Hypoxia Modulates Melanoma Cells Proliferation and Apoptosis via miRNA-210/ISCU/ROS Signaling

Autor:	D, Suwei, L, Zhen, L, Zhimin, L, Mei, K, Jianping, P, Zhuohui, X, Yanbin, M, Xiang
Rok vydání:	2021
Předmět:	Gene Expression Regulation Neoplastic Iron-Sulfur Proteins MicroRNAs Sulfonylurea Compounds Cell Line Tumor Humans Apoptosis Hypoxia Reactive Oxygen Species Melanoma Cell Proliferation
Zdroj:	Bulletin of experimental biology and medicine. 173(5)
ISSN:	1573-8221
Popis:	In this study, luciferase reporter assay was used to establish the relationship between miR-210 and ISCU. This research was performed on both cell lines (A2058, G361, and 293T) and tissue samples. We found that miR-210 was upregulated in hypoxia and was elevated in melanoma in comparison with adjacent normal tissues. Expression of ISCU protein was decreased in melanoma tissues, and ISCU gene is a direct target of miR-210. ISCU knockdown with miR-210 enhanced ROS production. The results of our study showed that miR-210/ISCU/ROS axis can serve as a novel therapeutic target in melanoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bdf1f75fb503e57a668a0ab37ea47a73 https://pubmed.ncbi.nlm.nih.gov/36210420 Zobrazit plný text záznamu Full text from SpringerLink