Long-term outcome in kidney transplant patients with hepatitis C (HCV) infection
| Autor: | S L, Orloff, C A, Stempel, T L, Wright, S J, Tomlanovich, W J, Amend, P G, Stock, J S, Melzer, F, Vincenti |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Adolescent Graft Survival Hepacivirus Middle Aged Hepatitis C Kidney Transplantation Hepatitis Cohort Studies Treatment Outcome Cause of Death Sepsis Prevalence Humans Female San Francisco Aspartate Aminotransferases Hepatitis Antibodies Child Liver Failure Aged Follow-Up Studies Hepatitis Chronic |
| Zdroj: | Clinical transplantation. 9(2) |
| ISSN: | 0902-0063 |
| Popis: | To assess the prevalence and long-term impact of HCV on kidney transplant recipients, we assayed 716 pre-transplant sera using a first-generation ELISA. The anti-HCV positive sera were confirmed by a 6-antigen radioimmunoassay (RIA). Patients were followed up for 5 years. Graft survival, function, evidence of chemical hepatitis (AST2x normal), patient mortality and cause of death were evaluated. The prevalence of anti-HCV antibody was 10.3%. In the 638 patients who were followed up for 5 years, there were no differences in graft function, graft survival, overall mortality, or death from sepsis or liver disease. Peak AST levels were significantly higher in anti-HCV positive patients compared to anti-HCV negative patients. At 5 years, the AST levels remained significantly higher in the anti-HCV positive group, however, this was only 6 U/1normal. Liver biopsies performed 3 to 7 years post-transplant in 80% of anti-HCV positive patients with chemical hepatitis showed 12% CAH, 50% mild hepatitis and 38% normal histology. Six (9.7%) patients seroconverted from anti-HCV positive to anti-HCV negative 2 to 5 years post-transplant. The presence of anti-HCV does not appear to alter long-term patient or graft survival, and histologic evidence of severe chronic liver disease was rare in anti-HCV positive patients with chemical hepatitis. From these results, the presence of anti-HCV antibody should not preclude kidney transplantation. |
| Databáze: | OpenAIRE |
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