Assessment of the association between the frequency of micronucleus and p

Autor:	G, Gashi, V, Mahovlić, E, Bahtiri, F, Kurshumliu, A, Podrimaj-Bytyqi, I R, Elezaj
Rok vydání:	2018
Předmět:	Ki-67 Antigen Micronucleus Tests Staining and Labeling Papillomavirus Infections Humans Uterine Cervical Neoplasms Female Middle Aged Reference Standards Cyclin-Dependent Kinase Inhibitor p16
Zdroj:	Biotechnichistochemistry : official publication of the Biological Stain Commission. 93(7)
ISSN:	1473-7760
Popis:	Human papilloma virus (HPV) infection is the main etiological factor for cervical intraepithelial lesions (CIN). An important characteristic of this process is the loss of genome stability. Therefore, it is imperative to use biomarkers of DNA damage caused by genomic instability to identify high risk individuals. We investigated the frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) of 20 patients, diagnosed as histologically CIN 1 and 10 healthy controls. We also examined the frequency of other nuclear anomalies including nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in PBL of patients with CIN 1 and healthy controls, and evaluated the benefits of p16
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bdc8747f8a229ddb628922e6c0460b15 https://pubmed.ncbi.nlm.nih.gov/29790789 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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