Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate

Autor:	V I, Bunik, A I, Biryukov, Zhukov YuN
Rok vydání:	1992
Předmět:	Kinetics Muscles Organophosphonates Animals Ketoglutaric Acids Ketoglutarate Dehydrogenase Complex Columbidae Methylation
Zdroj:	FEBS letters. 303(2-3)
ISSN:	0014-5793
Popis:	Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. alpha-Ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bdc20b2dac2c82200f2e7ed72899b38d https://pubmed.ncbi.nlm.nih.gov/1607019 Zobrazit plný text záznamu Plný text