[Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives]

Autor:	V L, Andronova, M V, Skorobogatyĭ, E V, Manasova, Iu A, Berlin, V A, Korshun, G A, Galegov
Rok vydání:	2003
Předmět:	Structure-Activity Relationship Cross-Linking Reagents Drug Resistance Multiple Viral Chemistry Organic Drug Evaluation Preclinical Animals Herpesvirus 1 Human Kidney Virus Replication Antiviral Agents Deoxyuridine Perylene Cells Cultured
Zdroj:	Bioorganicheskaia khimiia. 29(3)
ISSN:	0132-3423
Popis:	5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by cross-linking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bdbf83d5fd899fda3a1b946f7fa90af4 https://pubmed.ncbi.nlm.nih.gov/12845804 Zobrazit plný text záznamu