| Autor: |
Iu O, Fedotova, S G, Pivina, N É, Ordian |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 75(7) |
| ISSN: |
0869-2092 |
| Popis: |
The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptors antagonist NAN-190 (0.1 mg/kg, i.p.) for 14 days on anxiety-like behavior in prenatally stressed female with the experimental estrogen deficiency induced by ovariectomy. Chronic administration of 8-OH-DPAT to ovariectomized prenatally stressed females resulted in an anxiolytic effect and led to correction of the impaired levels of follitropine and estradiol. Administration of NAN-190 to ovariectomized prenatally stressed females increased the level of anxiety and more profoundly destroyed a relation between the levels of gonadotropic hormones and peripheral gonadal hormones. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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