Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b

Autor:	Katherine A, Gentry, G M, Anantharamaiah, Ayyalusamy, Ramamoorthy
Rok vydání:	2019
Předmět:	Models Molecular Cytochromes b5 Cytochrome P-450 Enzyme System Humans Oxidation-Reduction Article NADPH-Ferrihemoprotein Reductase Substrate Specificity
Zdroj:	Chem Commun (Camb)
ISSN:	1364-548X
Popis:	Cytochrome P450 (cytP450) interacts with two redox partners, cytP450 reductase and cytochrome-b(5), to metabolize substrates. Using NMR, we reveal changes in the dynamic interplay when all three proteins are incorporated into lipid nanodiscs in the absence and presence of substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bda28677cdac93861698d8eab7810ed2 https://pubmed.ncbi.nlm.nih.gov/31638629 Zobrazit plný text záznamu