The Use of the Comins-Meyers Amide in Synthetic Chemistry: an Overview

Autor: Serena, Monticelli, Giovanna, Parisi, Marta, Rui, Karen, de la Vega-Hernández, Irene, Murgia, Raffaele, Senatore, Wolfgang, Holzer, Ernst, Urban, Thierry, Langer, Vittorio, Pace
Rok vydání: 2018
Předmět:
Zdroj: Natural product communications. 11(11)
ISSN: 1934-578X
Popis: Formylation reactions are fundamental operations in synthetic chemistry allowing the incorporation into a given structure formyl groups amenable to further deiivatization. Conceptually, the introduction of such groups through the reaction between an electrophilic donor and a nucleophilic acceptor (i.e. organometallic reagent) constitutes a reliable technique with widespread applications. In this Highlight, we summarize the effectiveness of the so called Comnins-Meyers amide - [2-(N-methyl-N-formylamino]pyridine - in such a chemistry with vistas to the synthesis of natural products and biologically active substrates.
Databáze: OpenAIRE