Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico

Autor: María A, Loroño-Pino, José A, Farfán-Ale, Alicia L, Zapata-Peraza, Elsy P, Rosado-Paredes, Luis F, Flores-Flores, Julián E, García-Rejón, Francisco J, Díaz, Bradley J, Blitvich, Manuel, Andrade-Narváez, Eusebio, Jiménez-Ríos, Carol D, Blair, Ken E, Olson, William, Black, Barry J, Beaty
Rok vydání: 2004
Předmět:
Zdroj: The American journal of tropical medicine and hygiene. 71(4)
ISSN: 0002-9637
Popis: A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.
Databáze: OpenAIRE