Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis
| Autor: | D, Green, C H, Ts'ao, L, Cerullo, I, Cohen, T I, Ruo, A J, Atkinson |
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| Rok vydání: | 1985 |
| Předmět: |
Aminocaproates
Blood Platelets Hemostasis Bleeding Time Time Factors Platelet Aggregation Aorta Thoracic Intracranial Aneurysm Receptors Cell Surface Platelet Membrane Glycoproteins In Vitro Techniques Subarachnoid Hemorrhage Epoprostenol Tranexamic Acid Aminocaproic Acid Animals Humans Cattle Endothelium |
| Zdroj: | The Journal of laboratory and clinical medicine. 105(3) |
| ISSN: | 0022-2143 |
| Popis: | We previously reported that epsilon-aminocaproic acid (EACA) prolonged the bleeding time in patients with intracranial aneurysms when given in doses of 36 to 48 gm/day. We now show that doses of 24 gm/day also prolong the bleeding time, but only after 72 hours of continuous infusion. The effect on the bleeding time correlates with the duration of EACA therapy but not with the plasma level of the drug. Bleeding times return toward normal within 72 hours of discontinuing EACA infusions. The factors responsible for the bleeding time prolongation were investigated. In vitro, EACA inhibited adenosine diphosphate- and collagen-induced platelet aggregation and the release of platelet adenosine triphosphate and serotonin. It also prevented the adenosine diphosphate-stimulated binding of fibrinogen to intact as well as to chymotrypsin-treated platelets. However, platelets obtained from patients who had received EACA showed little functional impairment. This observation indicates that the focus of EACA activity in vivo is probably not the platelet per se, but the platelet-vessel wall interaction or a vascular component alone. EACA did not enhance prostacyclin production or release from cultured bovine endothelial cells. The fact that the effects of the drug on the bleeding time were related to the duration of EACA therapy suggests that an accumulation of the drug on the vessel wall may be required before alterations in hemostasis are observed. EACA in a daily dose of 24 gm significantly impaired fibrinolysis, but supranormal levels of fibrinolytic activity were observed within 72 hours of stopping the drug.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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