| Autor: |
Haiam Mohamed Mahmoud, Farrag, Enas Abdelhameed Mahmoud, Huseein, Nessren M, Abd El-Rady, Fatma Abdel Aziz Mohamed, Mostafa, Samah Saifeldin Merghani, Mohamed, Mona, Gaber |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Annals of parasitology. 67(2) |
| ISSN: |
2299-0631 |
| Popis: |
Trichinellosis is a common parasitic zoonosis. Complications of anthelmintic drugs combined with steroids raise the urge of alternative protective ways. The study aimed to investigate the protective effects of Lactobacillus acidophilus probiotic on both Trichinella spiralis adults and larvae in experimental animal models. Thirty-six male BALB/c mice were divided into 3 groups: negative control Group (G I); Group (G II) mice were inoculated orally by 500 Trichinella spiralis larvae; tested Group (G III) mice were prophylactic by an oral dose of Lactobacillus acidophilus in commercially available form for seven consecutive days, before infection. Mature worms and encysted larvae were counted on the 5th and 21st day post-infection (dpi), respectively. IL-1, IL-6, IL-10 and TNF-α concentrations were estimated at 5th and 21st dpi of all groups. Significant reductions in mean worms and larvae burden were detected by 62.1% and 73.5% in the prophylactic group compared to the non-prophylactic group. The cytokine profiles were revealed IL-1 and IL-6 up-regulation compared to IL-10 and TNF-α down-regulation in the tested group compared to other groups. Although Lactobacillus acidophilus failed to achieve complete eradication of Trichinella spiralis adults and larvae, it showed powerful effects in reducing parasites and cytokines burdens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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