Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB

Autor:	Malliga R, Iyer, Resat, Cinar, Alexis, Katz, Michael, Gao, Katalin, Erdelyi, Tony, Jourdan, Nathan J, Coffey, Pal, Pacher, George, Kunos
Rok vydání:	2017
Předmět:	Liver Cirrhosis Mice Structure-Activity Relationship Cricetulus Receptor Cannabinoid CB1 Cricetinae Drug Design Animals Brain Humans Nitric Oxide Synthase Type II CHO Cells Enzyme Inhibitors
Zdroj:	Journal of medicinal chemistry. 60(3)
ISSN:	1520-4804
Popis:	We report the design, synthesis, and structure-activity relationships of novel dual-target compounds with antagonist/inverse agonist activity at cannabinoid receptor type 1 (CB
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bd52aeb618efdae8b633a2748eef0616 https://pubmed.ncbi.nlm.nih.gov/28085283 Zobrazit plný text záznamu